PHAN Anh Tuan

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

Duplex stem-loops and four-stranded G-quadruplexes have been implicated in (patho)biological processes. Overlap of stem-loop- and quadruplex-forming sequences could give rise to quadruplex-duplex hybrids (QDH), which combine features of both structural forms and could exhibit unique properties. Here, we present a combined genomic and structural study of stem-loop-containing quadruplex sequences (SLQS) in the human genome. Based on a maximum loop length of 20 nt, our survey identified 80 307 SLQS, embedded within 60 172 unique clusters.

type: 
Journal Paper
journal: 
Nuclei Acids Research 2015, Vol. 43, No. 11, Pg 5630-5646, doi: 10.1093/nar/gkv355
pubmed: 
25958397
Url: 
http://nar.oxfordjournals.org/content/43/11/5630.long
Impact Factor: 
9.112
Date of acceptance: 
2016-01-06
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