TANG Zhiqun

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

BACKGROUND:
High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease aggressiveness and clinical outcomes. However, the functional relationships between microRNAs, the common pathways controlled by the microRNAs and their prognostic and therapeutic significance remain poorly understood.

METHODS:

type: 
Journal Paper
journal: 
BMC Genomics. 2017; 18(Suppl 6): 692, doi: 10.1186/s12864-017-4027-5
pubmed: 
28984201
Url: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629558/
Impact Factor: 
11.922

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candidate BC driver genes in an unbiased manner, using a stabilized N-terminal truncated β-catenin gene as a sensitizer. We identified 134 mouse susceptibility genes from 129 common insertion sites within 34 mammary tumors.

type: 
Journal Paper
journal: 
Proceedings of the National Academy of Sciences of the Unites States of America, PNAS, Vol. 114, No. 11, E2215–E2224, doi: 10.1073/pnas.1701512114
pubmed: 
28251929
Url: 
http://www.pnas.org/content/114/11/E2215.long?tab=author-info
Impact Factor: 
9.661

Big data and computational biology strategy for personalized prognosis

The era of big data and precision medicine has led to accumulation of massive datasets of gene expression data and clinical information of patients.

type: 
Journal Paper
journal: 
Oncotarget, 28 Jun 2016, Vol. 7, No. 26, Pg 40200-40220, doi: 10.18632/oncotarget.9571
pubmed: 
27229533
Url: 
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9571&pubmed-linkout=1
Impact Factor: 
5.008
Date of acceptance: 
2016-05-01
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