Predicting Allergenic Proteins Using Wavelet Transform

Published date : 29 Apr 2004

Motivation: With many transgenic proteins introduced today, the ability to predict their potential allergenicity has become an important issue. Previous studies were based on either sequence similarity or the protein motifs identified from known allergen databases. The similarity-based approaches, although being able to produce high recalls, usually have low prediction precisions. Previous motif-based approaches have been shown to be able to improve the precisions on cross-validation experiments.

type
Journal Paper
journal
Bioinformatics, 2004. 2004 Nov 1;20(16):2572-8, doi:10.1093/bioinformatics/bth286
Impact Factor
4.894

IgE antibody response to pork meat is prevalent among the asian population and may be under-recognised

Published date : 18 Apr 2004
type
Conference Paper/Poster
journal
9th International Symposium on Immunological, Chemical and Clinical problems of Food Allergy Budapest / Hungary, 18 - 21 April 2004
Impact Factor
NIL

G-PRIMER: Greedy Algorithm for Selecting Minimal Primer Set

Published date : 08 Apr 2004

 G-PRIMER, a web-based primer design program, has been developed to compute a minimal primer set specifically annealed to all the open reading frames in a given microbial genome. This program has been successfully used in the microarray experiment for analyzing the expression of genes in the Xanthomonas campestris genome.

type
Journal Paper
journal
Bioinformatics, Vol. 20 no. 15 2004, pages 2473-2475, doi:10.1093/bioinformatics/bth259
Impact Factor
4.894

Enhanced Quality and Quantity of Retrieval of Critically Appraised Topics Using the CAT Crawler

Published date : 01 Mar 2004

As healthcare moves towards the implementation of Evidence-Based Medicine (EBM), Critically Appraised Topics (CATs) become useful in helping physicians to make clinical decisions. A number of academic and healthcare organizations have set up web-based CAT libraries. The primary objective of the presented work is to provide a one-stop search and download site that allows access to multiple CAT libraries. A web-based application, namely the CAT Crawler, was developed to serve physicians with an adequate access to available appraised topics on the Internet.

type
Journal Paper
journal
Medical Informatics & the Internet in Medicine. Volume 29, Number 1, March, 2004 , pp. 43-55(13) DOI: 10.1080/14639230310001655849
Impact Factor
2.336

Rapid detection of conserved regions in protein sequences using wavelets

Published date : 08 Feb 2004

We present an algorithm to detect protein sub-structural motifs from primary sequence. The input to the algorithm is a set of aligned multiple protein sequences. It uses wavelet transforms to decompose protein sequences represented numerically by different indices (such as polarity, accessible surface area or electron-ion integration potentials of the amino acids). The numerical representation of a protein sequence has significant correlation with its biological activity, thus common motifs are expected to be observable from the wavelet spectrum.

type
Journal Paper
journal
In-Silico Biology 2004;4(2):133-48
Impact Factor
NIL