Enhanced Quality and Quantity of Retrieval of Critically Appraised Topics Using the CAT Crawler

Published date : 01 Mar 2004

As healthcare moves towards the implementation of Evidence-Based Medicine (EBM), Critically Appraised Topics (CATs) become useful in helping physicians to make clinical decisions. A number of academic and healthcare organizations have set up web-based CAT libraries. The primary objective of the presented work is to provide a one-stop search and download site that allows access to multiple CAT libraries. A web-based application, namely the CAT Crawler, was developed to serve physicians with an adequate access to available appraised topics on the Internet.

type
Journal Paper
journal
Medical Informatics & the Internet in Medicine. Volume 29, Number 1, March, 2004 , pp. 43-55(13) DOI: 10.1080/14639230310001655849
Impact Factor
2.336

Rapid detection of conserved regions in protein sequences using wavelets

Published date : 08 Feb 2004

We present an algorithm to detect protein sub-structural motifs from primary sequence. The input to the algorithm is a set of aligned multiple protein sequences. It uses wavelet transforms to decompose protein sequences represented numerically by different indices (such as polarity, accessible surface area or electron-ion integration potentials of the amino acids). The numerical representation of a protein sequence has significant correlation with its biological activity, thus common motifs are expected to be observable from the wavelet spectrum.

type
Journal Paper
journal
In-Silico Biology 2004;4(2):133-48
Impact Factor
NIL

Protein stability & ligand binding: new paradigms from in-silico experiments

Published date : 05 Jan 2004

Computer simulations are used to investigate two features of proteins: ligand binding and ligand entry/exit. Both reveal surprising new insights into the physics of such complex systems and suggest at possible interpretations that depart from the usual paradigms.

type
Journal Paper
journal
Biophysical Chemistry Volume 115, Issues 2-3, 1 April 2005, Pages 295-302, doi:10.1016/j.bpc.2004.12.038
Impact Factor
1.784

Alternatively spliced human genes by exon skipping - A database (ASHESdb)

Published date : 01 Jan 2004

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. Exon skipping is the most commonly known alternative splicing mechanism. A comprehensive database of alternative splicing by exon skipping is made available for the human genome data. 1,229 human genes are identified to exhibit alternative splicing by exon skipping.

type
Journal Paper
journal
In Silico Biology, 5, 0021
Impact Factor
NIL

A tabu search algorithm for post processing multiple sequence alignment

Published date : 01 Jan 2004

Tabu search is a meta-heuristic approach that is proven to be useful in solving combinatorial optimization problems. We implement the adaptive memory features of tabu search to refine a multiple sequence alignment. Adaptive memory helps the search process to avoid local optima and explores the solution space economically and effectively without getting trapped into cycles. The algorithm is further enhanced by introducing extended tabu search features such as intensification and diversification.

type
Journal Paper
journal
Journal of Bioinformatics and Computational Biology, 2004
Impact Factor
NIL