The next step in systems biology: simulating the temporospatial dynamics of molecular network

Published date : 29 Dec 2003

As a result of the time- and context-dependency of gene expression, gene regulatory and signaling pathways undergo dynamic changes during development. Creating a model of the dynamics of molecular interaction networks offers enormous potential for understanding how a genome orchestrates the developmental processes of an organism. The dynamic nature of pathway topology calls for new modeling strategies that can capture transient molecular links at the runtime.

type
Journal Paper
journal
BioEssays Vol (2004), 68-72
Impact Factor
NIL

ClustalW-MPI: ClustalW Analysis Using Distributed and Parallel Computing

Published date : 12 Aug 2003

ClustalW is a tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three steps: pairwise alignment, guide-tree generation and progressive alignment. ClustalW-MPI is a distributed and parallel implementation of ClustalW. All three steps have been parallelized to reduce the execution time. The software uses a message-passing library called MPI (Message Passing Interface) and runs on distributed workstation clusters as well as on traditional parallel computers.

type
Journal Paper
journal
Bioinformatics, 2003, 19(12), 1585-1586, doi:10.1093/bioinformatics/btg192
Impact Factor
4.926

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