OOI Hong Sain

Protein Sequence-Structure-Function-Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28

Published date : 19 Sep 2012

While very little genomic sequence is interpretable in terms of biological mechanism directly, the chances are much better for protein-coding genes that can be translated into protein sequences. This review considers the different concepts applicable to sequence analysis and function prediction of globular and non-globular protein segments. The publicly accessible ANNOTATOR software environment integrates most of the reliable protein sequence-based function prediction methods, protein domain databases and pathway, and protein–protein interaction collections developed in academia.

type
Book/Book Chapter
journal
Computational Medicine - Tools and Challenges, 2012, pg 111-143, ISBN 978-3-7091-0946-5

Databases of Protein-Protein Interactions and Complexes

Published date : 14 Dec 2009
type
Book/Book Chapter
journal
Data Mining Techniques for the Life Sciences, Section I: Databases, Pg 142-162 ISBN-10: 1603272402 (Humana Press)
Impact Factor
NIL

ANNIE : integrated de novo protein sequence annotation

Published date : 23 Apr 2009

Function prediction of proteins with computational sequence analysis requires the use of dozens of prediction tools with a bewildering range of input and output formats. Each of these tools focuses on a narrow aspect and researchers are having difficulty obtaining an integrated picture. ANNIE is the result of years of close interaction between computational biologists and computer scientists and automates an essential part of this sequence analytic process.

type
Journal Paper
journal
Nuclei Acids Research, 2009, Vol. 37, Web Server issue, W435-W440, doi: 10.1093/nar/gkp254
Impact Factor
NIL