Understanding the Functions of Peroxisomal Proteins: The Peroxisomal Proteome, Peroxisomal Import, Proteases and Other Protein Families and Their Network Organization: What Has Computational Biology Contributed?

Published date : 22 May 2014

Computational studies based on high-throughput experimental datasets, some of which were even not generated in the context of peroxisome research, have considerably shaped the understanding of the peroxisomal proteome. Most importantly, this research revealed to a considerable extent how the total peroxisomal proteome is composed and what is its network and pathway structure. Computational prediction tools have been instrumental for finding proteins that are imported into peroxisomes via canonical import mechanisms. Based on sequence homology considerations, functions of many experimentally uncharacterized proteins have been suggested and subsequently verified experimentally. As an example, the case of peroxisomal proteases is analyzed in detail. Additionally, resources such databases or WWW servers dedicated to peroxisomal biology are reviewed.

Book/Book Chapter
Molecular Machines Involved in Peroxisome Biogenesis and Maintenance, 2014, PG 187-232, doi: 10.1007/978-3-7091-1788-0_9