LIM Thiam C

‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing

Published date : 10 Feb 2013

Post-transcriptional switches are flexible effectors of dynamic changes in gene expression. Here we report a new post-transcriptional switch that dictates the spatiotemporal and mutually exclusive expression of two alternative gene products from a single transcript. Expression of primate-specific exonic microRNA-198 (miR-198), located in the 3'-untranslated region of follistatin-like 1 (FSTL1) messenger RNA, switches to expression of the linked open reading frame of FSTL1 upon wounding in a human ex vivo organ culture system.

Journal Paper
Nature, 10 Feb 2013, doi:10.1038/nature11890