ZHANG Jingxian

Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress

Published date : 29 May 2015

Oxidative stress (OS) is caused by an imbalance between pro- and anti-oxidant reactions leading to accumulation of reactive oxygen species within cells. We here investigate the effect of OS on the transcriptome of human fibroblasts. OS causes a rapid and transient global induction of transcription characterized by pausing of RNA polymerase II (PolII) in both directions, at specific promoters, within 30 minutes of the OS response.

Journal Paper
Scientific Reports 5,Article no: 9737, 2015, doi: 10.1038/srep09737