KHONG Zi Jian

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

Published date : 09 May 2015

Duplex stem-loops and four-stranded G-quadruplexes have been implicated in (patho)biological processes. Overlap of stem-loop- and quadruplex-forming sequences could give rise to quadruplex-duplex hybrids (QDH), which combine features of both structural forms and could exhibit unique properties. Here, we present a combined genomic and structural study of stem-loop-containing quadruplex sequences (SLQS) in the human genome. Based on a maximum loop length of 20 nt, our survey identified 80 307 SLQS, embedded within 60 172 unique clusters.

type
Journal Paper
journal
Nuclei Acids Research 2015, Vol. 43, No. 11, Pg 5630-5646, doi: 10.1093/nar/gkv355
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