TAN Kuan Pern

EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms

Published date : 02 Oct 2017

Recently, we reported that the histone methyltransferase, EZH2, controls leukocyte migration through interaction with the cytoskeleton remodeling effector, VAV, and direct methylation of the cytoskeletal regulatory protein, Talin. However, it is unclear whether this extranuclear, epigenetic-independent function of EZH2 has a profound impact on the initiation of cellular transformation and metastasis. Here, we show that EZH2 increases Talin1 methylation and cleavage, thereby enhancing adhesion turnover and promoting accelerated tumorigenesis.

Journal Paper
Oncogene 2017, Pg 1-17, doi:10.1038/onc.2017.309
Impact Factor