Antibody and Product Development

Commentary: Augmented Reality Scientific Phone Apps - making the APD AR Holistic Review app and using existing AR apps for scientific publications

Published date : 02 Oct 2018

The average scientific publication is not the most palatable of reading materials, especially to those not in the relevant disciplines. Yet, conveying scientific concepts easily is precisely what scientific publications are meant to do. Imagine what the use of video pictures/paintings as depicted in the Harry Potter movie series can do to make things easier! While the fantasy of moving photos/pictures does not exist physically in the real world, just as Santa Claus cannot travel the world today without being shot down by anti-missiles, there are some shadows of reality in this idea.

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Journal Paper
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Scientific Phone Apps and Mobile Devices (2018) 4:4, doi:10.30943/2018/28092018

Editorial : A New Home for "Scientific Phone Apps and Mobile Devices" Journal

Published date : 28 Sep 2018

The original intent of academic publication to disseminate information and findings to the community for scientific progress has taken different twists and turns particularly in the last few decades. With the Internet, there is now the option of E-publications, and more recently, open access publishing to make articles freely available to readers. No longer are the articles restricted to subscribing academics, but now also to the general public.

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Journal Paper
journal
Scientific Phone Apps and Mobile Devices (2018) 4:3, doi: 10.30943/2018/26042018

The Associations between Dietary Practices and Dietary Quality, Biological Health Indicators, Perceived Stress, Religiosity, Culture, and Gender in Multi-Cultural Singapore

Published date : 29 Jul 2018

Dietary quality, biological health, culture, religiosity, and perceived stress are co-related. However, there is a dearth of research conducted on Asian populations in secularized and harmonious multi-cultural societies. This study addresses these gaps by conducting an investigation in the multi-cultural and multi-religious Singapore to examine the parameters of culture and gender and the associations with 1) dietary quality, 2) biological health indicators, 3) religiosity, and perceived stress.

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Journal Paper
journal
Journal of Ethnic Foods, 2018, doi: 10.1016/j.jef.2018.07.003

Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding

Published date : 08 Jun 2018

Therapeutic antibodies have shifted the paradigm of disease treatments from small molecules to biologics, especially in cancer therapy. Despite the increasing number of antibody candidates, much remains unknown about the antibody and how its various regions interact. Recent findings showed that the antibody constant region can govern localization effects that are useful in reducing side effects due to systemic circulation by the commonly used IgG isotypes. Given their localized mucosal effects, IgA antibodies are increasingly promising therapeutic biologics.

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Journal Paper
journal
Antibodies 2018, 7(2), 20, doi: 10.3390/antib7020020

Role of FcαR EC2 region in extracellular membrane localization

Published date : 05 Apr 2018

The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1–2]. FcαR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic tail region [3]. Previously, we reported that the EC1 region plays an essential role for extracellular membrane localization of the receptor [4], where the absence of EC1 would prevent the variants from localizing to the cell surface, even with a full signal peptide.

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Journal Paper
journal
Cell Cycle, 2018, doi: 10.1080/15384101.2018.1444236
Impact Factor
3.530

Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding

Published date : 14 Mar 2018

Many therapeutic antibodies are humanized from animal sources. In the humanization process, complementarity determining region grafting is tedious and highly prone to failure. With seven known VH families, and up to six known κ VL families, there are choices aplenty. However, the functions of these families remain largely enigmatic. To study the role of these V-region families, we made 84 recombinant combinations of the various VH and VL family whole IgG1 variants of both Trastuzumab and Pertuzumab.

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Journal Paper
journal
Frontiers in Immunology, 12 March 2018, Vol. 9, Article: 469, doi: org/10.3389/fimmu.2018.00469
Impact Factor
6.429

The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding

Published date : 15 Jan 2018

Current therapeutic antibodies such as Trastuzumab, are typically of the blood circulatory IgG1 class (Cκ/ CHγ1). Due to the binding to Her2 also present on normal cell surfaces, side effects such as cardiac failure can sometimes be associated with such targeted therapy. Using antibody isotype swapping, it may be possible to reduce systemic circulation through increased tissue localization, thereby minimising unwanted side effects. However, the effects of such modifications have yet to be fully characterized, particularly with regards to their biophysical properties in antigen binding.

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Journal Paper
journal
Scientific Reports 8, Article no 718, 2018, doi:10.1038/s41598-017-18892-9
Impact Factor
4.259