Gunalan V

AllerCatPro - Prediction of protein allergenicity potential from the protein sequence

Published date : 18 Jan 2019

MOTIVATION:
Due to the risk of inducing an immediate type I (IgE-mediated) allergic response, proteins intended for use in consumer products must be investigated for their allergenic potential before introduction into the marketplace. The FAO/WHO guidelines for computational assessment of allergenic potential of proteins based on short peptide hits and linear sequence window identity thresholds misclassify many proteins as allergens.

type
Journal Paper
journal
Bioinformatics. 2019 Jan 18. doi: 10.1093/bioinformatics/btz029
Impact Factor
5.481

The Geographic Variation of Surveillance and Zoonotic Spillover Potential of Influenza Viruses in Domestic Poultry and Swine

Published date : 27 Nov 2018

Background
Avian and swine influenza viruses circulate worldwide and pose threats to both animal and human health. The design of global surveillance strategies is hindered by information gaps on the geospatial variation in virus emergence potential and existing surveillance efforts.

type
Journal Paper
journal
Open Forum Infectious Diseases, Vol. 5, issue 12, 1 Dec 2018, doi: 10.1093/ofid/ofy318
Impact Factor
3.240

Molecular Evidence of Transmission of Influenza A/H1N1 2009 on a University Campus

Published date : 06 Jan 2017

Background
In the recent years, the data on the molecular epidemiology of influenza viruses have expanded enormously because of the availability of cutting-edge sequencing technologies. However, much of the information is from the temperate regions with few studies from tropical regions such as South-east Asia. Despite the fact that influenza has been known to transmit rapidly within semi-closed communities, such as military camps and educational institutions, data are limited from these communities.

Objectives

type
Journal Paper
journal
PLOS ONE, 2017,12 (1), doi: 10.1371/journal.pone.0168596
Impact Factor
2.806

A large common-source outbreak of norovirus gastroenteritis in a hotel in Singapore, 2012

Published date : 28 Oct 2016

An outbreak of gastroenteritis affected 453 attendees (attack rate 28·5%) of six separate events held at a hotel in Singapore. Active case detection, case-control studies, hygiene inspections and microbial analysis of food, environmental and stool samples were conducted to determine the aetiology of the outbreak and the modes of transmission. The only commonality was the food, crockery and cutlery provided and/or handled by the hotel's Chinese banquet kitchen. Stool specimens from 34 cases and 15 food handlers were positive for norovirus genogroup II.

type
Journal Paper
journal
Epidemiology & Infection 2016, Pg 1-10, DOI: 10.1017/S095026881600248X
Impact Factor
2.4

Identification of a Lineage D Betacoronavirus in Cave Nectar Bats (Eonycteris spelaea) in Singapore and an Overview of Lineage D Reservoir Ecology in SE Asian Bats

Published date : 16 Sep 2016

Coronaviruses are a diverse group of viruses that infect mammals and birds. Bats are reservoirs for several different coronaviruses in the Alphacoronavirus and Betacoronavirus genera. They also appear to be the natural reservoir for the ancestral viruses that generated the severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus outbreaks. Here, we detected coronavirus sequences in next-generation sequence data created from Eonycteris spelaea faeces and urine.

type
Journal Paper
journal
Transboundary and Emerging Diseases, 2016 Sep 16. doi: 10.1111/tbed.12568
Impact Factor
2.714

Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia

Published date : 15 Jun 2015

During November 2012–July 2013, a marked increase of adenovirus type 7 (Ad7) infections associated with severe disease was documented among pediatric patients in Singapore. Phylogenetic analysis revealed close genetic links with severe Ad7 outbreaks in China, Taiwan, and other parts of Asia.

type
Journal Paper
journal
Emerging Infectious Diseases, Vol. 21, No. 7, July 2015, doi: 10.3201/eid2107.141443
Impact Factor
7.327

Evolutionary trajectories and diagnostic challenges of potentially zoonotic avian influenza viruses H5N1 and H9N2 co-circulating in Egypt

Published date : 03 Jun 2015

In Egypt, since 2006, descendants of the highly pathogenic avian influenza virus (HP AIV) H5N1 of clade 2.2 continue to cause sharp losses in poultry production and seriously threaten public health. Potentially zoonotic H9N2 viruses established an endemic status in poultry in Egypt as well and co-circulate with HP AIV H5N1 rising concerns of reassortments between H9N2 and H5N1 viruses along with an increase of mixed infections of poultry.

type
Journal Paper
journal
Infection, Genetics and Evolution, 2015, S1567-1348(15)00236-1. doi: 10.1016/j.meegid.2015.06.004
Impact Factor
3.015

Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany

Published date : 01 May 2015

Highly pathogenic avian influenza (H5N8) virus, like the recently described H5N8 strain from Korea, was detected in November 2014 in farmed turkeys and in a healthy common teal (Anas crecca) in northeastern Germany. Infected wild birds possibly introduced this virus.

type
Journal Paper
journal
Emerging Infectious Diseases, Vol. 21, No. 5, May 2015, Pg 860-863, doi: 10.3201/eid2105.141897, PMID: 25897703
Impact Factor
7.327

The contrasting phylodynamics of human influenza B viruses

Published date : 16 Jan 2015

A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden.

type
Journal Paper
journal
eLIFE 2015 Jan 16;4. doi: 10.7554/eLife.05055
Impact Factor
8.519

Emergence of norovirus GI.2 outbreaks in military camps in Singapore

Published date : 18 Dec 2014

Background: Simultaneous acute gastroenteritis (AGE) outbreaks occurred at two military camps. This study details the epidemiological findings, explores possible origins, and discusses preventive measures.

type
Journal Paper
journal
International Journal of Infectious Diseases, Feb 2015, Vol. 31, Pg 23-30, doi: 10.1016/j.ijid.2014.12.023
Impact Factor
2.33