Wong Alex

Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment

Published date : 27 Nov 2018

Aberrant lipid accumulation is a hallmark of cancer known to contribute to its aggressiveness and malignancy. Emerging studies have demonstrated context-dependent changes in lipid metabolism during chemotherapy. However, there is little known regarding the mechanisms linking lipid metabolism to chemotherapy-induced cell fates. Here, we describe lipid accumulation in cells following antimitotic drug treatment. Cells arrested in mitosis, as well as cells that escaped mitotic arrest and underwent mitotic slippage, showed elevated cytoplasmic lipid droplets.

Journal Paper
Cell Death Discovery 4, Article no: 109. 2018, doi: 10.1038/s41420-018-0127-5