Koh Cheng Gee

Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns

Published date : 22 Jun 2018

Endothelial cells adopt unique cell fates during sprouting angiogenesis, differentiating into tip or stalk cells. The fate selection process is directed by Delta-Notch lateral inhibition pathway. Classical Delta-Notch models produce a spatial pattern of tip cells separated by a single stalk cell, or the salt-and-pepper pattern. However, classical models cannot explain alternative tip-stalk patterning, such as tip cells that are separated by two or more stalk cells.

type
Journal Paper
journal
Scientific Reports 8, No. 9519, 2018, doi: 10.1038/s41598-018-27645-1
Impact Factor
4.122

Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals

Published date : 01 Apr 2014

Intracellular transport of proteins by motors along cytoskeletal filaments is crucial to the proper functioning of many eukaryotic cells. Since most proteins are synthesized at the cell body, mechanisms are required to deliver them to the growing periphery. In this article, we use computational modeling to study the strategies of protein transport in the context of JNK (c-JUN NH2-terminal kinase) transport along microtubules to the terminals of neuronal cells.

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Journal Paper
journal
PLoS ONE, April 2014, Vol. 9, Issue 4. doi: 10.1371/journal.pone.0092437
Impact Factor
3.534

POPX2 Phosphatase Regulates the KIF3 Kinesin Motor Complex

Published date : 11 Dec 2013

The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this study, we have identified POPX2, a serine-threonine phosphatase, as an interacting partner of the KAP3 subunit of the kinesin-2 motor. The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo.

type
Journal Paper
journal
Journal of Cell Science 2013, Dec 11, doi: 10.1242/​jcs.126482
Impact Factor
5.817