SINGH Malay

Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma

Published date : 12 Dec 2017

Currently, molecular markers are not used when determining the prognosis and treatment strategy for patients with hepatocellular carcinoma (HCC). In the present study, we proposed that the identification of common pro-oncogenic pathways in primary tumors (PT) and adjacent non-malignant tissues (AT) typically used to predict HCC patient risks may result in HCC biomarker discovery. We examined the genome-wide mRNA expression profiles of paired PT and AT samples from 321 HCC patients.

type
Journal Paper
journal
Molecular Oncology, 8 Nov 2017, doi: 10.1002/1878-0261.12153
Impact Factor
5.314

Gland segmentation in prostatehistopathological images

Published date : 21 Jun 2017

Glandular structural features are important for the tumor pathologist in the assessment of cancer malignancy of prostate tissue slides. The varying shapes and sizes of glands combined with the tedious manual observation task can result in inaccurate assessment. There are also discrepancies and low-level agreement among pathologists, especially in cases of Gleason pattern 3 and pattern 4 prostate adenocarcinoma. An automated gland segmentation system can highlight various glandular shapes and structures for further analysis by the pathologist.

type
Journal Paper
journal
Journal of Medical Imaging, 2017 Apr;4(2):027501, doi: 10.1117/1.JMI.4.2.027501

A Study of Nuclei Classification Methods in Histopathological Images

Published date : 21 May 2017

Cancer is a group of diseases involving abnormal cell growth with varying malignancy and extent across different patients. Cytological features like prominent nucleoli, nuclear enlargement, and hyperchromasia are important to the tumor pathologist in assessment of cancer malignancy from tissue biopsies. In a recent study, Yap et al. [21] proposed effective prominent nucleoli detectors in histopathological images and developed different feature generation methods.

type
Conference Paper/Poster
journal
Proceedings of the 5th KES International Conference on Innovation in Medicine and Healthcare (KES-InMed 2017)

Automated Image Based Prominent Nucleoli Detection

Published date : 23 Jun 2015

Nucleolar changes in cancer cells are one of the cytologic features important to the tumor pathologist in cancer assessments of tissue biopsies. However, inter-observer variability and the manual approach to this work hamper the accuracy of the assessment by pathologists. In this paper, we propose a computational method for prominent nucleoli pattern detection. Materials and Methods: Thirty-five hematoxylin and eosin stained images were acquired from prostate cancer, breast cancer, renal clear cell cancer and renal papillary cell cancer tissues.

type
Journal Paper
journal
Journal of Pathology Informatics 2015, Vol. 6, Issue 1,doi: 10.4103/2153-3539.159232