Chong Kian-Tai

Gland segmentation in prostatehistopathological images

Published date : 21 Jun 2017

Glandular structural features are important for the tumor pathologist in the assessment of cancer malignancy of prostate tissue slides. The varying shapes and sizes of glands combined with the tedious manual observation task can result in inaccurate assessment. There are also discrepancies and low-level agreement among pathologists, especially in cases of Gleason pattern 3 and pattern 4 prostate adenocarcinoma. An automated gland segmentation system can highlight various glandular shapes and structures for further analysis by the pathologist.

type
Journal Paper
journal
Journal of Medical Imaging, 2017 Apr;4(2):027501, doi: 10.1117/1.JMI.4.2.027501

Automated Image Based Prominent Nucleoli Detection

Published date : 23 Jun 2015

Nucleolar changes in cancer cells are one of the cytologic features important to the tumor pathologist in cancer assessments of tissue biopsies. However, inter-observer variability and the manual approach to this work hamper the accuracy of the assessment by pathologists. In this paper, we propose a computational method for prominent nucleoli pattern detection. Materials and Methods: Thirty-five hematoxylin and eosin stained images were acquired from prostate cancer, breast cancer, renal clear cell cancer and renal papillary cell cancer tissues.

type
Journal Paper
journal
Journal of Pathology Informatics 2015, Vol. 6, Issue 1,doi: 10.4103/2153-3539.159232