Doupe David

Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration

Published date : 04 Apr 2017

Understanding the mechanisms of collective cell migration is crucial for cancer metastasis, wound healing and many developmental processes. Imaging a migrating cluster in vivo is feasible, but the quantification of individual cell behaviours remains challenging. We have developed an image analysis toolkit, CCMToolKit, to quantify the Drosophila border cell system. In addition to chaotic motion, previous studies reported that the migrating cells are able to migrate in a highly coordinated pattern.

type
Journal Paper
journal
Nature Communications, 2017 Apr 4;8:14905. doi: 10.1038/ncomms14905
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