Yarmishyn Aliaksandr

Genome-wide analysis of mRNAs associated with mouse peroxisomes

Published date : 22 Dec 2016

Background: RNA is often targeted to be localized to the specific subcellular compartments. Specific localization of mRNA is believed to be an important mechanism for targeting their protein products to the locations, where their function is required.

type
Journal Paper
journal
BMC Genomics 2016, 17 (Supp 13), 1028, doi: 10.1186/s12864-016-3330-x
Impact Factor
3.869

Sense-antisense gene-pairs in breast cancer and associated pathological pathways

Published date : 28 Oct 2015

More than 30% of human protein-coding genes form hereditary complex genome architectures composed of sense-antisense (SA) gene pairs (SAGPs) transcribing their RNAs from both strands of a given locus. Such architectures represent important novel components of genome complexity contributing to gene expression deregulation in cancer cells. Therefore, the architectures might be involved in cancer pathways and, in turn, be used for novel drug targets discovery. However, the global roles of SAGPs in cancer pathways has not been studied.

type
Journal Paper
journal
Oncotarget. 2015 Dec 8;6(39):42197-221. doi: 10.18632/oncotarget.6255
Impact Factor
6.359

Long noncoding RNAs: a potential novel class of cancer biomarkers

Published date : 23 Apr 2015

Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. They constitute a major, but still poorly characterized part of human transcriptome, however, evidence is growing that they are important regulatory molecules involved in various cellular processes. It is becoming increasingly clear that many lncRNAs are deregulated in cancer and some of them can be important drivers of malignant transformation.

type
Journal Paper
journal
Frontiers in Genetics, April 2015, Vol. 6, Article 145, doi:10.3389/fgene.2015.00145

HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome

Published date : 08 Dec 2014

Background
Long noncoding RNAs (lncRNAs) constitute a major, but poorly characterized part of human transcriptome. Recent evidence indicates that many lncRNAs are involved in cancer and can be used as predictive and prognostic biomarkers. Significant fraction of lncRNAs is represented on widely used microarray platforms, however they have usually been ignored in cancer studies.

Results

type
Journal Paper
journal
BMC Genomics 2014, 15(Suppl 9):S7 doi:10.1186/1471-2164-15-S9-S7
Impact Factor
4.04