LI Kuo-Bin

The Human Intermediate Filament Database

Published date : 20 May 2006

We describe a revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton. The family of 70 intermediate filament genes (including those encoding keratins, desmins, and lamins) is now known to be associated with a wide range of diverse diseases, at least 72 distinct human pathologies, including skin blistering, muscular dystrophy, cardiomyopathy, premature aging syndromes, neurodegenerative disorders, and cataract.

Conference Paper/Poster
Gordon Research Conference : Intermediate Filaments, Newport. 20 - 24 May 2006
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Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multiple support vector machines

Published date : 13 Jul 2005


Predicting the subcellular localization of proteins is important for determining the function of proteins. Previous works focused on predicting protein localization in Gram-negative bacteria obtained good results. However, these methods had relatively low accuracies for the localization of extracellular proteins. This paper studies ways to improve the accuracy for predicting extracellular localization in Gram-negative bacteria.

Journal Paper
BMC Bioinformatics 2005 Jul 13;6:174, doi:10.1186/1471-2105-6-174
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