Bone and the Kidney: A Systems Biology Approach to the Molecular Mechanisms of Renal Osteodystrophy

Published date : 01 Aug 2005

Despite its apparent static condition, the skeleton undergoes a permanent process of remodeling mediated by osteoblasts and osteoclasts. The activity of these cells is regulated by a plethora of factors, ranging from mechanical stress to the effects of hormones to the immune system. One well-studied regulatory system involves the maintenance of calcium homeostasis through a network whose main regulatory components include ionized calcium, phosphate, parathyroid hormone and active vitamin D.

Journal Paper
Current Molecular Medicine. 2005 Aug;5(5):489-96
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