LIEW Lailing

Nuclear import of a lipid-modified transcription factor: Mobilization of NFAT5 isoform a by osmotic stress

Published date : 15 Nov 2011

Lipid-modified transcription factors (TFs) are biomolecular oddities since their reduced mobility and membrane attachment appear to contradict nuclear import required for their gene-regulatory function. NFAT5 isoform a (selected from an in silico screen for predicted lipid-modified TFs) is shown to contribute about half of all endogenous expression of human NFAT5 isoforms in the isotonic state. Wild-type NFAT5a protein is indeed myristoylated and palmitoylated on its transport to the plasmalemma via the endoplasmic reticulum and the Golgi.

type
Journal Paper
journal
Cell Cycle, Vol 10, Issue 22, Nov 15 2011, Pg 3897 - 3911
Impact Factor
5

Signalling Networks in Mesenchymal Stem Cells

Published date : 06 Mar 2009
type
Book/Book Chapter
journal
Regulatory Networks in Stem Cells, 1st edition, 2009 (Stem Cell Biology and Regenerative Medicine),Pg 329-336, ISBN : 978-1-60327-226-1
Impact Factor
NIL

GCBKB: An Integrated Resource for Gastric Cancer Biomarker Discovery

Published date : 04 Dec 2006
type
Conference Paper/Poster
journal
Joint Third Asian Oceanian Human Proteome Organization (AOHUPO) and Fourth Structural Biology and Functional Genomics Conference, Singapore. 4 - 7 Dec 2006
Impact Factor
NIL