Background: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide due to poor
patient prognosis and clinical outcome. Here, we studied the genetic variations underlying NSCLC pathogenesis
based on their association to patient outcome after gemcitabine therapy.
Results: Bioinformatics analysis was used to investigate possible effects of POLA2 G583R (POLA2+1747 GG/GA,
dbSNP ID: rs487989) in terms of protein function. Using biostatistics, POLA2+1747 GG/GA (rs487989, POLA2 G583R)