ZHANG Zong Hong

Cube - an online tool for comparison and contrasting of protein sequences

Published date : 20 Nov 2013

When comparing sequences of similar proteins, two kinds of questions can be asked, and the related two kinds of inference made. First, one may ask to what degree they are similar, and then, how they differ. In the first case one may tentatively conclude that the conserved elements common to all sequences are of central and common importance to the protein’s function. In the latter case the regions of specialization may be discriminative of the function or binding partners across

type
Journal Paper
journal
PLoS One, Nov 2013, Vol. 8, Issue 11, doi:10.1371/journal.pone.0079480
Impact Factor
3.73

Defining the phenotype in congenital disorder of glycosylation due to ALG1 mutations.

Published date : 10 Sep 2012

Deficiency of β-1,4 mannosyltransferase (MT-1) congenital disorder of glycosylation (CDG), due to ALG1 gene mutations. Features in 9 patients reported previously consisted of prenatal growth retardation, pregnancy-induced maternal hypertension and fetal hydrops. Four patients died before 5 years of age, and survivors showed a severe psychomotor retardation. We report on 7 patients with psychomotor delay, microcephaly, strabismus and coagulation abnormalities, seizures and abnormal fat distribution. Four children had a stable clinical course, two had visual impairment, and 1 had hearing loss.

type
Journal Paper
journal
Pediatrics Vol. 130 No. 4, 1 Oct 2012, pg 1034-1039 doi: 10.1542/peds.2011-2711
Impact Factor
5.391

Cube-DB: detection of functional divergence in human protein families

Published date : 01 Dec 2011

Cube-DB is a database of pre-evaluated results for detection of functional divergence in human/vertebrate protein families. The analysis is organized around the nomenclature associated with the human proteins, but based on all currently available vertebrate genomes. Using full genomes enables us, through a mutual-best-hit strategy, to construct comparable taxonomical samples for all paralogues under consideration. Functional specialization is scored on the residue level according to two models of behavior after divergence: heterotachy and homotachy.

type
Journal Paper
journal
Nucl. Acids Res. (2011) doi: 10.1093/nar/gkr1129

Determinants, discriminants, conserved residues - a heuristic approach to detection of functional divergence in protein families.

Published date : 12 Sep 2011

In this work, belonging to the field of comparative analysis of protein sequences, we focus on detection of functional specialization on the residue level. As the input, we take a set of sequences divided into groups of orthologues, each group known to be responsible for a different function.THIS PROVIDES TWO INDEPENDENT PIECES OF INFORMATION: within group conservation and overlap in amino acid type across groups.

type
Journal Paper
journal
PLoS ONE, Sept 2011, Vol. 6, Issue 9
Impact Factor
4.4