Bharatham Kavitha

Cube-DB: detection of functional divergence in human protein families

Published date : 01 Dec 2011

Cube-DB is a database of pre-evaluated results for detection of functional divergence in human/vertebrate protein families. The analysis is organized around the nomenclature associated with the human proteins, but based on all currently available vertebrate genomes. Using full genomes enables us, through a mutual-best-hit strategy, to construct comparable taxonomical samples for all paralogues under consideration. Functional specialization is scored on the residue level according to two models of behavior after divergence: heterotachy and homotachy.

type
Journal Paper
journal
Nucl. Acids Res. (2011) doi: 10.1093/nar/gkr1129

Determinants, discriminants, conserved residues - a heuristic approach to detection of functional divergence in protein families.

Published date : 12 Sep 2011

In this work, belonging to the field of comparative analysis of protein sequences, we focus on detection of functional specialization on the residue level. As the input, we take a set of sequences divided into groups of orthologues, each group known to be responsible for a different function.THIS PROVIDES TWO INDEPENDENT PIECES OF INFORMATION: within group conservation and overlap in amino acid type across groups.

type
Journal Paper
journal
PLoS ONE, Sept 2011, Vol. 6, Issue 9
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