Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage

Published date : 04 Oct 2012

It has been established that low concentrations of hydrogen peroxide (H2O2) are produced in wounds and is required for optimal healing. Yet at the same time, there is evidence that excessive oxidative damage is correlated with poor-healing wounds. In this paper, we seek to determine whether topical application of H2O2 can modulate wound healing and if its effects are related to oxidative damage. Using a C57BL/6 mice excision wound model, H2O2 was found to enhance angiogenesis and wound closure at 10 mM but retarded wound closure at 166 mM.

Journal Paper
PLoS ONE Nov 2012, Vol. 7, Issue 11, doi: 10.1371/journal.pone.0049215
Impact Factor