Phua SX

Role of the IgE variable heavy chain in FcεRIa and superantigen binding in allergy and immunotherapy

Published date : 14 Apr 2019

Background
Variable heavy chain (VH) family frameworks (FWRs) have been reported to affect antibody receptor and superantigen binding; however, such effects in IgE remain largely unknown. Given that VH family biases have been previously reported in IgE of certain allergies, there is a need to investigate this phenomenon for biotechnological and therapeutic purposes.

type
Journal Paper
journal
Journal of Allergy and Clinical Immunology, April 2019, doi : 10.1016/j.jaci.2019.03.028
Impact Factor
13.258

Perspective: The promises of a holistic view of proteins-impact on antibody engineering and drug discovery

Published date : 10 Jan 2019

The reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the sum of its parts. With experimental, technological and computational advances, we can now do more than view parts in isolation, thus wepropose that an increasing holistic view (where a protein is investigated as much as a whole as possible) is now timely. To further advocate this, we review and discuss several studies and applications involving allostery,where distant protein regions can cross-talk to influence functionality.

type
Journal Paper
journal
Bioscience Reports, Jan 10, 2019, DOI: 10.1042/BSR20181958
Impact Factor
2.899