Tan J

Oncogenic activation of STAT3 pathway drives PD-L1 expression in natural killer/T cell lymphoma

Published date : 27 Jul 2018

Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas with dismal outcomes and limited treatment options. To determine the extent of involvement of JAK/STAT pathway in this malignancy, we performed targeted capture sequencing of 188 genes in this pathway in 171 PTCL and NKTL cases. A total of 272 non-synonymous somatic mutations in 101 genes were identified in 73% of the samples, including 258 single nucleotide variants and 14 insertions or deletions.

type
Journal Paper
journal
Blood 2018 Jul 27, doi: 10.1182/blood-2018-01-829424
Impact Factor
15.132

Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis

Published date : 17 May 2017

BACKGROUND:
An outbreak of Zika virus infection was detected in Singapore in August, 2016. We report the first comprehensive analysis of a national response to an outbreak of Zika virus infection in Asia.

METHODS:

type
Journal Paper
journal
The Lancet Infectious Diseases, Vol. 17, No. 8, pg 813-821, Aug 2017, doi: 10.1016/S1473-3099(17)30249-9
Impact Factor
19.864