Napoletano F

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Published date : 22 Mar 2019

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly controlled by a complex and well-characterized feedback mechanism mediated by cholesterol, a crucial bio-product of the SREBP-activated mevalonate pathway.

Journal Paper
Nature Communications, 2019 Mar 22;10(1):1326. doi: 10.1038/s41467-019-09152-7
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