Bond PJ
Antibacterial and Anti-Inflammatory Effects of Apolipoprotein E
Keywords: apolipoprotein E; antimicrobial peptides; Gram-negative bacteria; host defense; innate immunity; aggregation
ReadUncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
The COVID-19 pandemic has prompted a rapid response in vaccine and drug development. Herein, we modeled a complete membrane-embedded SARS-CoV-2 spike glycoprotein and used molecular dynamics simulations with benzene probes designed to enhance discovery of cryptic pockets.
ReadMotional clustering in supra-τ c conformational exchange influences NOE cross-relaxation rate
Biomolecular spin relaxation processes, such as the NOE, are commonly modeled by rotational -tumbling combined with fast motions on the sub- timescale. Motions on the supra- timescale, in contrast, are considered to be completely decorrelated to the molecular tumbling and therefore invisible.
ReadAllosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein
Keywords: SARS-CoV-2; Spike protein; allosteric drugs; allosteric effects of mutations; allostery; drug design; druggability; mutability.
ReadAllosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein
Keywords: SARS-CoV-2; Spike protein; allosteric drugs; allosteric effects of mutations; allostery; drug design; druggability; mutability.
ReadManipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria
Synthetic β-hairpin antimicrobial peptides (AMPs) offer a useful source for the development of novel antimicrobial agents. β-hairpin peptides generally consist of two side strands bridged by a reverse turn. In literature, most studies focused on the modifications of the side strands to manipulate the stability and activity of β-hairpin peptides, and much less is known about the impact of the turn region.
ReadSomatic genetic rescue of a germline ribosome assembly defect
Indirect somatic genetic rescue (SGR) of a germline mutation is thought to be rare in inherited Mendelian disorders. Here, we establish that acquired mutations in the EIF6 gene are a frequent mechanism of SGR in Shwachman-Diamond syndrome (SDS), a leukemia predisposition disorder caused by a germline defect in ribosome assembly.
ReadThe nanotube express: Delivering a stapled peptide to the cell surface
Hypothesis Carbon nanotubes (CNTs) represent a novel platform for cellular delivery of therapeutic peptides. Chemically-functionalized CNTs may enhance peptide uptake by improving their membrane targeting properties.
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