Elucidating the effect of poly(ethylene terephthalate) chain structure on its enzymatic degradation behaviour

Polyethylene terephthalate, chemical modification, crystallinity, structural characterization, thermal properties, enzymatic degradation

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Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription.

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Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

DAXX (Death Domain Associated Protein 6), initially identified as a potentiator of apoptosis, is known to play crucial roles in several vital biological pathways, including chromatin remodeling, transcription regulation, DNA repair, and innate immunity. Its increased expression has been observed in diverse, epidemiologically prevalent cancers

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Shape complementarity processes for ultrashort-burst sensitive M13-PEG-WS2-powered MCF-7 cancer cell sensors

Biomarkers have the potential to be utilized in disease diagnosis, prediction and monitoring. The cancer cell type is a leading candidate for next-generation biomarkers.

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The Singapore National Precision Medicine Strategy

Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine.

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The First Quarter Century of the Dense Alignment Surface Transmembrane Prediction Method

Keywords: transmembrane proteins; transmembrane prediction; multiple sequence alignment; dot-plots

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Whole Genomic Characterization of Streptococcus iniae Isolates from Barramundi (Lates calcarifer) and Preliminary Evidence of Cross-Protective Immunization

Lates calcarifer, also known as Barramundi or Asian seabass, is a highly productive and fast-growing species that is well suited to large-scale aquaculture due to its attractive harvestable yields (premium fish). This fish has been envisioned as having the potential to be the “Salmon of Tropics”. Cultivating Lates calcarifer in aquaculture poses challenges, as the dense populations that make such aquaculture commercially viable facilitate the rapid spread of infectious diseases, which in turn significantly impact yield

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Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma

Combination therapy with radioembolization (yttrium-90)-resin microspheres) followed by nivolumab has shown a promising response rate of 30.6% in a Phase II trial (CA209-678) for advanced hepatocellular carcinoma (HCC); however, the response mechanisms and relevant biomarkers remain unknown.

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