Cesare AJ
Critical role for cold shock protein YB-1 in cytokinesis
High levels of the cold shock protein Y-box-binding protein-1, YB-1, are tightly correlated with increased cell proliferation and progression. However, the precise mechanism by which YB-1 regulates proliferation is unknown.
ReadDephosphorylation of YB-1 is Required for Nuclear Localisation During G2 Phase of the Cell Cycle
YB-1; cell cycle; nuclear translocation; atomistic modelling; phosphorylation
ReadDephosphorylation of YB-1 is Required for Nuclear Localisation During G2 Phase of the Cell Cycle
Elevated levels of nuclear Y-box binding protein 1 (YB-1) are linked to poor prognosis in cancer. It has been proposed that entry into the nucleus requires specific proteasomal cleavage. However, evidence for cleavage is contradictory and high YB-1 levels are prognostic regardless of cellular location.
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