Cheng L
Hepatic mitochondrial NAD+ transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis
SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown. We aimed to investigate the physiological role of SLC25A47 in hepatic metabolism.
ReadAblation of H+/glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis
Solute carrier transporters are the second largest family of membrane proteins responsible for the transport of various substances such as saccharides, lipids, amino acids, and inorganic ions across cellular membranes (Zhang et al., 2019). One third of all solute carriers such as SLC2, SLC22, and SLC45 subfamily belong to the major facilitator superfamily clan (Chen et al., 2014; Perland et al., 2017).
ReadAblation of H+/glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis
Solute carrier transporters are the second largest family of membrane proteins responsible for the transport of various substances such as saccharides, lipids, amino acids, and inorganic ions across cellular membranes (Zhang et al., 2019). One third of all solute carriers such as SLC2, SLC22, and SLC45 subfamily belong to the major facilitator superfamily clan (Chen et al., 2014; Perland et al., 2017). The majority of major facilitator superfamily proteins are generated from a single two-transmembrane segment hairpin structure that triplicated to give a six two-transmembrane segment unit and then duplicated to a 12-two-transmembrane segment protein (Reddy et al., 2012). The most widely accepted working model for transporters is the alternating access mechanism with alternated facilitated access to binding sites on either side of the membrane (Diallinas, 2014).
ReadSLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility
Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa mid-piece and show by genetic, biochemical, multi-omic, and nutritional evidence that riboflavin transport deficiency suppresses the oxidative phosphorylation and reprograms spermatozoa energy metabolism by disrupting flavoenzyme functions.
ReadSupervised Segmentation of Un-annotated Retinal Fundus Images by Synthesis
We focus on the practical challenge of segmenting new retinal fundus images that are dissimilar to existing well-annotated datasets. It is addressed in this paper by a supervised learning pipeline, with its core being the construction of a synthetic fundus image dataset using the proposed R-sGAN technique.
ReadSynthesizing retinal and neuronal images with generative adversarial nets
This paper aims at synthesizing multiple realistic-looking retinal (or neuronal) images from an unseen tubular structured annotation that contains the binary vessel (or neuronal) morphology. The generated phantoms are expected to preserve the same tubular structure, and resemble the visual appearance of the training images.
ReadMultivariate Regression with Gross Errors on Manifold-valued Data
We consider the topic of multivariate regression on manifold-valued output, that is, for a multivariate observation, its output response lies on a manifold. Moreover, we propose a new regression model to deal with the presence of grossly corrupted manifold-valued responses, a bottleneck issue commonly encountered in practical scenarios.
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