Hartono YD
Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases
Keywords: cannabinoid biosynthesis; cannabinoid synthase; berberine bridge enzyme; cannabielsoin; cannabigerolic acid; Pichia pastoris
ReadStructure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production
Synthetic biology efforts for cannabinoid research have seen a rapid expansion in recent years. This is in response to the increasing awareness and legalization of the secondary metabolites from Cannabis sativa, dubbed the green rush.
ReadStructure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production
KEYWORDS: cannabinoid biosynthesis, computational protein engineering, synthetic biology, enzyme design, prenyltransferase
ReadRecent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
Keywords: lipid GPCR; ligand access; orthosteric and allosteric binding sites; drug discovery; antibody; computational methods; prostaglandin receptor; platelet-activating factor receptor; sphingosine-1-phosphate receptor; lysophosphatidic acid receptor; leukotriene receptor; free fatty acid receptor; cannabinoid receptor
ReadBiosynthesis of Nature-Inspired Unnatural Cannabinoids
Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a wide range of bioactivities and recently seen significant developments in their status as therapeutic agents for various indications.
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