Hiller S
Motional clustering in supra-τ c conformational exchange influences NOE cross-relaxation rate
Biomolecular spin relaxation processes, such as the NOE, are commonly modeled by rotational -tumbling combined with fast motions on the sub- timescale. Motions on the supra- timescale, in contrast, are considered to be completely decorrelated to the molecular tumbling and therefore invisible.
ReadThe antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the antimicrobial resistance crisis1,2,3. Gram-negative bacteria are protected by an additional outer membrane, rendering proteins on the cell surface attractive drug targets4,5.
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