Huang J
Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
Keywords: Childhood obesity, mother–offspring cohort, growth trajectories, BMI z-score trajectories, group-based trajectory modelling, risk factors for childhood obesity
ReadStructure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme in steroid metabolism and catalyzes the reduction of testosterone to dihydrotestosterone. Mutations in the SRD5A2 gene have been linked to 5α-reductase deficiency and prostate cancer. Finasteride and dutasteride, as SRD5A2 inhibitors, are widely used antiandrogen drugs for benign prostate hyperplasia.
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