Kairon RS and Chiam KH

A review of algorithmic approaches for cell culture media optimization

Cell culture is widely used in biotechnology to manufacture various useful products for applications such as pharmaceuticals, food, biofuel, and industrial products. Cell culture production systems in industry and research span different kingdoms of life from free living microbes such as bacteria, archaea, and fungi, to cell lines derived from multicellular organisms including insect and mammalian species. Products include pharmaceuticals such as antibiotics and monoclonal antibodies; food products such as rennet, single-cell protein, and cultivated meat; biofuel from lipid-producing algae; industrial products such as cleaning enzymes and organic acids.