Lee RTC
Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave
COVID-19 vaccines have been essential in bringing the pandemic under control. They have shown to be highly efficacious against severe diseases
ReadHeterologous mRNA vaccine boosters induce a stronger and longer-lasting antibody response against Omicron XBB variant
The SARS-CoV-2 Omicron recombinant XBB subvariant was first detected in September 2022, and rapidly spread across South-East Asia, notably overtaking BA.5 to become the dominant variant in Singapore.
ReadOutbreak.info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations
In response to the emergence of SARS-CoV-2 variants of concern, the global scientific community, through unprecedented effort, has sequenced and shared over 11 million genomes through GISAID, as of May 2022.
ReadMADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Egg
Keywords: egg passage adaptation; vaccine effectiveness; influenza H3N2 virus; adaptive evolution; vaccine production
ReadResistance of SARS-CoV-2 Delta variant to neutralization by BNT162b2-elicited antibodies in Asians
SARS-CoV-2 was first detected in late December 2019, however, in the few months that followed, the resultant COVID-19 disease has developed into a devastating pandemic around the world [[1]]. This has led to a race to produce a safe and efficacious vaccine in record time.
ReadBioinformatics-aided identification, characterization and applications of mushroom linalool synthases
Enzymes empower chemical industries and are the keystone for metabolic engineering. For example, linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60–80% cosmetic and personal care products.
ReadLongitudinal sampling is required to maximize detection of intrahost A/H3N2 virus variants
Seasonal human influenza viruses continually change antigenically to escape from neutralizing antibodies. It remains unclear how genetic variation in the intrahost virus population and selection at the level of individual hosts translates to the fast-paced evolution observed at the global level because emerging intrahost antigenic variants are rarely detected.
ReadDiscovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion in SARS-CoV-2 that truncates open reading frame 7b (ORF7b) and ORF8, removing the ORF8 transcription regulatory sequence (TRS) and eliminating ORF8 transcription.
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