Li X
Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5
Mounting evidence have revealed that despite the high degree of sequence homology between cytochrome P450 3A isoforms (i.e. CYP3A4 and CYP3A5), they have the propensities to exhibit vastly different irreversible and reversible interactions with a single substrate. We have previously established that benzbromarone (BBR), a potent uricosuric agent utilized in the management of gout, irreversibly inhibits CYP3A4 via mechanism-based inactivation (MBI).
ReadHybrid AI assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears
Technical advancements significantly improve earlier diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various factors. We develop an artificial intelligence assistive diagnostic solution, AIATBS, to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria.
ReadAtopic Dermatitis Classification Models of 3D Optoacoustic Mesoscopic Images
A comprehensive analysis using three machine-learning models for an AI-aided atopic dermatitis (AD) diagnosis and sub-classifying AD severities with 3D Raster Scanning Optoacoustic Mesoscopy (RSOM) images, extracted features from volumetric vascular structures and clinical information.
ReadModel Learning Analysis of 3D Optoacoustic Mesoscopic Images for the Classification of Atopic Dermatitis
Atopic dermatitis (AD) is a skin inflammatory disease affecting 10% of the population worldwide. Raster-scanning optoacoustic mesoscopy (RSOM) has recently shown promise in dermatological imaging.
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