Lin J
Defining neutralization and allostery by antibodies against COVID-19 variants
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies.
ReadDefining neutralization and allostery by antibodies against COVID-19 variants
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked to their quaternary changes occurring as a result of antibody-Spike trimer interactions. Here, we reveal the conformational dynamics and allosteric perturbations linked to binding of novel human antibodies and the viral Spike protein.
ReadBioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics
Keywords : Peptide hydrogel, Supramolecular self-assembly, Drug delivery, Secretome, Wound healing
ReadBioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics
A short bioinspired octapeptide, GV8, can self-assemble under mild conditions into biodegradable supramolecular physical hydrogels with high [storage modulus](https://www.sciencedirect.com/topics/materials-science/elastic-moduli "Learn more about storage modulus from ScienceDirect's AI-generated Topic Pages") and good biocompatibility.
ReadPlasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells
More than one-third of the world’s population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2,3,4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6,7,8,9,10.
ReadHybrid AI assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears
Technical advancements significantly improve earlier diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various factors. We develop an artificial intelligence assistive diagnostic solution, AIATBS, to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria.
Read