Loh XJ
A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway
Aberrant wound healing, which leads to irreversible fibrosis, underpins many pathological diseases. In the eye, this manifests as proliferative vitreoretinopathy (PVR), a major cause of poor vision due to failed retinal detachment (RD) surgery1,2. PVR occurs due to proliferative and contractile fibrocellular scar membranes that form either in the vitreous or surrounding the retina.
ReadStructure mapping of dengue and Zika viruses reveals functional long-range interactions
Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus function. Here, we perform structure and interaction mapping on four DENV and ZIKV strains inside virions and in infected cells. Comparative analysis of SHAPE reactivities across serotypes nominates potentially functional regions that are highly structured, conserved, and contain low synonymous mutation rates.
Read