Nguyen NM
Drug Repurposing and Multi-Target Therapies
Since biological systems are often complex and comprising networks of multiple, interacting genes and their products, polypharmacology-based drug repurposing has gained wider acceptance in recent years. We discuss the benefits and drawbacks of drug repurposing.
ReadStructural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites
Catalytic proteins such as human protein tyrosine phosphatase 1B (PTP1B), with conserved and highly polar active sites, warrant the discovery of druggable nonactive sites, such as allosteric sites, and potentially, therapeutic small molecules that can bind to these sites. Catalyzing the dephosphorylation of numerous substrates, PTP1B is physiologically important in intracellular signal transduction pathways in diverse cell types and tissues.
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