Samsudin F
Mechanisms of allostery at the viral surface through the eyes of molecular simulation
The outermost surface layer of any virus is formed by either a capsid shell or envelope. Such layers have traditionally been thought of as immovable structures, but it is becoming apparent that they cannot be viewed exclusively as static architectures protecting the viral genome.
ReadBioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation.
Of more than 300 million surgical procedures performed worldwide annually,[1] almost 10% develop surgical site infections (SSIs).[2] SSIs account for a substantial clinical and economic burden.[3] Although many factors contribute to SSIs, preventive measures before, during, and after surgery can lower the SSI incidence.[4] Causes of SSIs vary depending on anatomy, surgical procedure, and exogenous in addition to endogenous, patient-derived factors. Bacterial contamination is one cause that can be controlled.[4, 5] In hospitals, preventive measures such as hygiene routines are implemented but even under sterile surgical conditions, infections may occur due to the spread of bacteria from the patient's own bacterial flora.[6] It has also been reported that up to 60% of the bacteria recovered from infected surgical wounds developed antibiotic resistance.[7]
ReadMembrane platform protein PulF of the Klebsiella type II secretion system forms a trimeric ion channel essential for endopilus assembly and protein secretion
Type IV pili and type II secretion systems (T2SS) are crucial for bacterial adaptation, virulence, and environmental impact. A common mechanism underlying their multiple functions involves assembly of dynamic plasma membrane-anchored filaments—the (endo)pili.
ReadDefining neutralization and allostery by antibodies against COVID-19 variants
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies.
ReadDefining neutralization and allostery by antibodies against COVID-19 variants
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked to their quaternary changes occurring as a result of antibody-Spike trimer interactions. Here, we reveal the conformational dynamics and allosteric perturbations linked to binding of novel human antibodies and the viral Spike protein.
ReadTargeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.
There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection.
ReadSpike-Independent Infection of Human Coronavirus 229E in Bat Cells
Many viruses, including coronaviruses, originated from bats. Yet, we know little about how these viruses switch between hosts and enter human populations. Coronaviruses have succeeded in establishing in humans at least five times, including endemic coronaviruses and the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
ReadObservation of multiple protein temperature transitions dependent upon the chemical environment
Surgical site infections (SSI) are a clinical and economic burden. Suture-associated SSI may develop when bacteria colonize the suture surface and form biofilms that are resistant to antibiotics.
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