Shimamura S
A Web Server for GPCR-GPCR Interaction Pair Prediction
G Protein-Coupled Receptors (GPCRs) form higher-order molecular complexes (oligomers) with other GPCRs. The molecular functions of such oligomers differ from those of monomers with respect to at least one of the following examples: endogenous ligand binding, coupling with trimeric G-proteins, expression levels on membrane, and intracellular trafficking. The regulatory chemicals of oligomer formation are likely to work by different mechanisms from those of the existing GPCR-targeted chemicals (1–6). GPCR-GPCR interactions are unique in that GPCRs with different molecular functions interact with each other and exert molecular functions that are completely different from those of the monomers, as reviewed previously (7–9). GPCR hetero-dimers are considered to be novel therapeutic targets (10).
ReadCorrigendum: A Web Server for GPCR-GPCR Interaction Pair Prediction
G Protein-Coupled Receptors (GPCRs) form higher-order molecular complexes (oligomers) with other GPCRs. The molecular functions of such oligomers differ from those of monomers with respect to at least one of the following examples: endogenous ligand binding, coupling with trimeric G-proteins, expression levels on membrane, and intracellular trafficking. The regulatory chemicals of oligomer formation are likely to work by different mechanisms from those of the existing GPCR-targeted chemicals (1–6). GPCR-GPCR interactions are unique in that GPCRs with different molecular functions interact with each other and exert molecular functions that are completely different from those of the monomers, as reviewed previously (7–9). GPCR hetero-dimers are considered to be novel therapeutic targets (10).
Read