Bioinformatics Institute

Bioinformatics Institute

Repository of all published Science Articles by our Researchers, their Group Members and Collaborators.

Bioinformatics Institute
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    Tan KP

    Packpred: Predicting the Functional Effect of Missense Mutations

    Keywords: amino acid depth; local environment/clique; meta predictor; missense mutation effect prediction; statistical potential

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    Packpred: Predicting the Functional Effect of Missense Mutations

    Amino acid substitutions could affect protein stability, alter/impair its function, and possibly lead to disease conditions (Zhang et al., 2012). Several such single amino acid substitutions in proteins, also called missense mutations, are implicated in diseases such as cystic fibrosis, diabetes, cancer etc.

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