Tao L
Hepatic mitochondrial NAD+ transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis
SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown. We aimed to investigate the physiological role of SLC25A47 in hepatic metabolism.
ReadAblation of H+/glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis
Solute carrier transporters are the second largest family of membrane proteins responsible for the transport of various substances such as saccharides, lipids, amino acids, and inorganic ions across cellular membranes (Zhang et al., 2019). One third of all solute carriers such as SLC2, SLC22, and SLC45 subfamily belong to the major facilitator superfamily clan (Chen et al., 2014; Perland et al., 2017).
ReadAblation of H+/glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis
Solute carrier transporters are the second largest family of membrane proteins responsible for the transport of various substances such as saccharides, lipids, amino acids, and inorganic ions across cellular membranes (Zhang et al., 2019). One third of all solute carriers such as SLC2, SLC22, and SLC45 subfamily belong to the major facilitator superfamily clan (Chen et al., 2014; Perland et al., 2017). The majority of major facilitator superfamily proteins are generated from a single two-transmembrane segment hairpin structure that triplicated to give a six two-transmembrane segment unit and then duplicated to a 12-two-transmembrane segment protein (Reddy et al., 2012). The most widely accepted working model for transporters is the alternating access mechanism with alternated facilitated access to binding sites on either side of the membrane (Diallinas, 2014).
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