Wang J
MADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Egg
Keywords: egg passage adaptation; vaccine effectiveness; influenza H3N2 virus; adaptive evolution; vaccine production
ReadMolecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C
The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to “bumpy” surfaced morphology when the temperature is switched from 29°C at 37°C.
Read