Yang H
Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis
Focal adhesions (FAs) play an important role in sensing mechanical cues in the extracellular matrix and transducing forces from the extracellular matrix into biological signals (Riveline et al., 2001). The cells can sense and respond to changes in the rigidity of the underlying substrates. When cells are grown on substrates of varying rigidity, they exert larger traction stress and migrate towards more rigid substrates in a phenomenon known as durotaxis (Lo et al., 2000). In order to sense substrate rigidity, the cells apply traction stress through FAs and actin stress fibres to measure mechanical responses of the substrate (Discher et al., 2005; Kobayashi and Sokabe, 2010; Prager-Khoutorsky et al., 2011). While the FA structure of mouse fibroblasts has been elucidated at the nanoscale level (Kanchanawong et al., 2010), little is known about the substrate rigidity sensing mechanisms of the cell.
ReadBioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics
Keywords : Peptide hydrogel, Supramolecular self-assembly, Drug delivery, Secretome, Wound healing
ReadBioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics
A short bioinspired octapeptide, GV8, can self-assemble under mild conditions into biodegradable supramolecular physical hydrogels with high [storage modulus](https://www.sciencedirect.com/topics/materials-science/elastic-moduli "Learn more about storage modulus from ScienceDirect's AI-generated Topic Pages") and good biocompatibility.
ReadTargeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide
Sal-like 4 (SALL4) is a nuclear factor central to the maintenance of stem cell pluripotency and is a key component in hepatocellular carcinoma, a malignancy with no effective treatment. In cancer cells, SALL4 associates with nucleosome remodeling deacetylase (NuRD) to silence tumor-suppressor genes, such as PTEN.
Read