Protein Sequence Analysis
The Singapore National Precision Medicine Strategy
Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine.
ReadApplication of AllerCatPro 2.0 for protein safety assessments of consumer products
Foreign proteins are potentially immunogenic, and a proportion of these are able to induce immune responses that result in allergic sensitization. Subsequent exposure of sensitized subjects to the inducing protein can provoke a variety of allergic reactions that may be severe, or even fatal. It has therefore been recognized for some time that it is important to determine a priori whether a given protein has the potential to induce allergic responses in exposed subjects.
ReadOutbreak.info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations
In response to the emergence of SARS-CoV-2 variants of concern, the global scientific community, through unprecedented effort, has sequenced and shared over 11 million genomes through GISAID, as of May 2022.
ReadMonkeypox Virus Infection in 2 Female Travelers Returning to Vietnam from Dubai, United Arab Emirates, 2022
Mpox was diagnosed in 2 women returning to Vietnam from the United Arab Emirates. The monkeypox viruses belonged to an emerging sublineage, A.2.1, distinct from B.1, which is responsible for the ongoing multicountry outbreak.
ReadMADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Egg
Keywords: egg passage adaptation; vaccine effectiveness; influenza H3N2 virus; adaptive evolution; vaccine production
ReadAllerCatPro 2.0: a web server for predicting protein allergenicity potential
Proteins in food and personal care products can pose a risk for an immediate immunoglobulin E (IgE)-mediated allergic response. Bioinformatic tools can assist to predict and investigate the allergenic potential of proteins. Here we present AllerCatPro 2.0, a web server that can be used to predict protein allergenicity potential with better accuracy than other computational methods and new features that help assessors making informed decisions.
ReadA Web Server for GPCR-GPCR Interaction Pair Prediction
G Protein-Coupled Receptors (GPCRs) form higher-order molecular complexes (oligomers) with other GPCRs. The molecular functions of such oligomers differ from those of monomers with respect to at least one of the following examples: endogenous ligand binding, coupling with trimeric G-proteins, expression levels on membrane, and intracellular trafficking. The regulatory chemicals of oligomer formation are likely to work by different mechanisms from those of the existing GPCR-targeted chemicals (1–6). GPCR-GPCR interactions are unique in that GPCRs with different molecular functions interact with each other and exert molecular functions that are completely different from those of the monomers, as reviewed previously (7–9). GPCR hetero-dimers are considered to be novel therapeutic targets (10).
ReadCorrigendum: A Web Server for GPCR-GPCR Interaction Pair Prediction
G Protein-Coupled Receptors (GPCRs) form higher-order molecular complexes (oligomers) with other GPCRs. The molecular functions of such oligomers differ from those of monomers with respect to at least one of the following examples: endogenous ligand binding, coupling with trimeric G-proteins, expression levels on membrane, and intracellular trafficking. The regulatory chemicals of oligomer formation are likely to work by different mechanisms from those of the existing GPCR-targeted chemicals (1–6). GPCR-GPCR interactions are unique in that GPCRs with different molecular functions interact with each other and exert molecular functions that are completely different from those of the monomers, as reviewed previously (7–9). GPCR hetero-dimers are considered to be novel therapeutic targets (10).
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