Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma
This study unraveled extensive molecular changes underlying distinctive responses to the novel treatment and pinpointed new directions for harnessing combination therapy in patients with advanced HCC
ReadApplication of AllerCatPro 2.0 for protein safety assessments of consumer products
Foreign proteins are potentially immunogenic, and a proportion of these are able to induce immune responses that result in allergic sensitization. Subsequent exposure of sensitized subjects to the inducing protein can provoke a variety of allergic reactions that may be severe, or even fatal. It has therefore been recognized for some time that it is important to determine a priori whether a given protein has the potential to induce allergic responses in exposed subjects.
ReadSystems Biology and Omics Approaches for Complex Human Diseases
For many years, there has been general interest in developing virtual cells or digital twin models [1,2]. This is due to (i) a purely curiosity-driven need to build theories of life and, (ii) the potential to quickly and safely find cures for diseases by testing drugs in silico before testing them on actual organisms.
ReadGlobally invariant behavior of oncogenes and random genes at population but not at single cell level
Cancer is widely considered a genetic disease. Notably, recent works have highlighted that every human gene may possibly be associated with cancer. Thus, the distinction between genes that drive oncogenesis and those that are associated to the disease, but do not play a role, requires attention
ReadA novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma
This study identified potential salivary exosome-derived miRNA biomarkers and crucial miRNA-mRNA networks/underlying mechanisms responsible for OSCC progression.
ReadA sweeter future: Using protein language models for exploring sweeter brazzein homologs
The dramatic rise in obesity and diabetes in recent decades has seen the widespread use of artificial sweeteners in food and drinks as sugar replacements (Gardner et al., 2012). By replacing sugar with these artificial sweeteners, blood glucose level can be better regulated and calorie consumption reduced whilst maintaining food palatability with its sweet taste (Gardner et al., 2012). However, recent data around the detrimental side effects of consuming artificial sweeteners highlight the need for other sweeteners (Bueno-Hernández et al., 2019, Debras et al., 2022, Debras et al., 2022, Suez et al., 2014).
ReadSafety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Keywords: carotenoids; Asian women; gene expression; mood; physical activity; fecal microbiome
ReadA high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays
Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function.
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