Defining neutralization and allostery by antibodies against COVID-19 variants
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked to their quaternary changes occurring as a result of antibody-Spike trimer interactions. Here, we reveal the conformational dynamics and allosteric perturbations linked to binding of novel human antibodies and the viral Spike protein.
Read222-D Automated hyperplex staining and imaging system on various cancer tissues using off the shelf antibodies
Interactions between tumor and neighboring immune cells are dynamic and complex within the tumor microenvironment (TME), requiring the use of spatial biology techniques to characterize them, and thereby identify potential targets for immunotherapy.
ReadTranscriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription
Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription.
ReadStitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
DAXX (Death Domain Associated Protein 6), initially identified as a potentiator of apoptosis, is known to play crucial roles in several vital biological pathways, including chromatin remodeling, transcription regulation, DNA repair, and innate immunity. Its increased expression has been observed in diverse, epidemiologically prevalent cancers
ReadShape complementarity processes for ultrashort-burst sensitive M13-PEG-WS2-powered MCF-7 cancer cell sensors
Biomarkers have the potential to be utilized in disease diagnosis, prediction and monitoring. The cancer cell type is a leading candidate for next-generation biomarkers.
ReadTargeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.
There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection.
ReadThe Singapore National Precision Medicine Strategy
Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine.
ReadElucidating the effect of poly(ethylene terephthalate) chain structure on its enzymatic degradation behaviour
Polyethylene terephthalate (PET) is a widely used thermoplastic polymer, but its excessive use and poor waste management pose environmental challenges.
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